Here we present an instructional model for undergraduate students to gain experience in protein modeling and to describe a molecular story. Initially run as an independent study course for a few students at a time, the experience developed into an interdisciplinary course co-taught by faculty in different departments. This course is available to students regardless of major, academic level, or previous college-level experience. Five groups of three students each, were tasked with researching and developing a molecular story that would be enhanced using a 3D-printed model. Each group was composed of students from varying academic levels and majors to facilitate a collaborative, project-based learning approach. Students used various protein-focused bioinformatics tools to develop their story and model. Peer mentors who previously participated in a protein modeling project assisted students. Primary literature, course materials, and protein modeling tools provided students with the ability to learn the scientific process, apply it to understand molecular mechanisms, and disseminate their work. All finished projects included a protein model description sheet, poster, oral presentations, Jmol script, and 3-D printed protein model. Many participants went on to present models at local, national, and international conferences. To better understand student learning gained as part of this experience, a tailored RISC (Research on the Integrated Science Curriculum) Survey was administered at the end of the semester. This course represents a successful example of a course-based undergraduate research opportunity (CURE) that can be replicated in a wide variety of institutions and provide research opportunities for many students.

Participants will be able to:

1. Identify important features on a protein macromolecule

2. Utilize computational resources to discover and refine protein function

3. Produce a protein model

4. Participate in a scientific presentation that highlights structure/function understanding

5. Solve problems using interdisciplinary concepts and skills