Presenters:
Brianna Brourke, Marqus Colon, and Emily Schmitt
This session introduces a practical model for integrating protein structure exploration, digital tools, and narrative case studies to deepen student engagement in molecular biology. Participants will experience “Missy’s Story,” a case study that investigates how a rare IDH2 mutation contributes to acute myeloid leukemia and how targeted therapy helps restore cellular function. Originally developed in an undergraduate honors project on protein modeling, this case has since evolved into an interactive instructional tool.
Using the Molecular Case Net framework and resources such as Jmol and the RCSB Protein Data Bank, attendees will be guided through activities that mirror student learning: identifying key mutations, analyzing ligand binding, and visualizing drug-enzyme interactions in 3D. The session demonstrates how structure-based storytelling can make complex biochemistry content more accessible and relevant, while encouraging collaboration.
The interactive portion will allow participants to work through segments of the digital workbook, showcasing how these tools and narratives can be applied in classrooms. Intended for science educators, this session offers a replicable approach to teaching molecular concepts in a way that centers on human impact and inquiry. Participants will leave with access to resources, implementation strategies, and a compelling example of how molecular modeling can promote meaningful student learning.
